What makes a drug a blockbuster — or a cautionary tale?

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Hey there. Today, we talk about how biomanufacturing is getting a huge boost in North Carolina, study a new potential root for autoimmune disease in women, and more.

The need-to-know this morning

• Bristol Myers Squibb reported fourth quarter and 2023 earnings. For 2024, the company said it expects total sales to increase “low single digits” from $45 billion in 2023. Current Street consensus has Bristol growing sales 2%.
• More earnings: Regeneron Pharmaceuticals and Abbvie.

What makes a blockbuster?

Can biotech learn from Aduhelm? And how do you replace a singular regulator? We cover all that and more this week on “The Readout LOUD,” STAT’s biotech podcast.

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